Key result
Post-OHT depression is linked to ~65% more hospitalizations but similar 5-year survival.
Why the study?
Does the identification and treatment of depression impact mortality, hospitalizations, and rejection in patients after orthotopic heart transplantation?
Cohort (n=102)
No
Does the identification and treatment of depression impact mortality, hospitalizations, and rejection in patients after orthotopic heart transplantation?
Absolute Event Rate: 4.3% vs 2.6%
p-value: p=0.05
Identification and treatment of depression in heart transplant patients is associated with similar 5-year survival and rejection rates compared to nondepressed patients, despite a higher rate of all-cause hospitalizations.
Depressed OHT recipients showed similar survival but more hospitalizations; leaves open whether identification or treatment modifies post-transplant outcomes.
Background. The effects of clinical depression after orthotopic heart transplantation (OHT) are relatively unknown. The purpose of this study was to evaluate the impact of depression on outcomes after OHT. Methods. We performed a single center retrospective review of 102 consecutive patients who underwent OHT at Northwestern Memorial Hospital from June 2005 to October 2009. The diagnosis of depression was obtained from attending physician documentation. The primary endpoints were all-cause mortality (ACM), hospitalizations, and rejection. Results. Of 102 OHT patients, 26 (26%) had depression. Depressed patients were similar in age to nondepressed patients (57.6 years versus 56.9, P = 0.79). There was no statistical difference in survival between groups at 5 years after OHT (P = 0.94). All-cause hospitalizations were higher in depressed versus nondepressed patients (4.3 versus 2.6 hospitalizations P = 0.05). There were no significant differences in hospitalizations between the two groups for the following complications: cardiac (heart failure, edema, arrhythmias, and acute rejection) and infections. There was no significant difference in episodes of 2R and 3R rejection. Conclusion. Early identification and treatment of depression in OHT patients result in outcomes similar to nondepressed patients.
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Okwuosa et al. (2014) conducted a cohort in Orthotopic heart transplantation (n=102). Depression vs. No depression was evaluated on All-cause mortality (ACM), hospitalizations, and rejection (p=0.05). Depression after orthotopic heart transplantation was associated with higher all-cause hospitalizations (4.3 vs 2.6, P=0.05) but no significant difference in 5-year survival (P=0.94).
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