Key result
Depressive symptoms link to ~132% higher all-cause mortality in heart transplant patients.
Why the study?
The impact of depression on prognosis and mortality in heart transplantation patients has not been sufficiently established.
Do depressive symptoms increase mortality in heart transplantation patients?
Cross-Sectional (n=147)
Do depressive symptoms increase mortality in heart transplantation patients?
Answers are grounded in this paper and cite their sources.
Depressive symptoms independently predict mortality in heart transplant recipients, highlighting the clinical importance of routine screening in this population.
BACKGROUND: Several studies indicate that heart transplantation (HTx) is associated with depression and reduced quality of life. However, the impact of depression on the prognosis for HTx-patients has not yet been sufficiently established. The aim of the present study was to prospectively investigate the influence of depression on mortality in patients with HTx, adjusting for other known risk factors. METHODS: In a prospective, cross-sectional study with minimum 5-year follow-up, symptoms of depression were assessed in 147 HTx-patients using the Beck Depression Inventory (BDI). RESULTS: Mild to severe depressive symptoms (BDI > or =10) were observed in 36 patients (24.5%). Depressive symptoms on inclusion increased the risk of mortality during the follow-up period. The risk remained significant after adjusting for several somatic and lifestyle risk factors, and the adjusted relative risk associated with depression (risk ratio: 2.32; 95% CI: 1.13-4.79; P=0.02) was comparable to the adjusted relative risk associated with time since HTx. CONCLUSIONS: Symptoms of depression predict mortality independently of somatic and lifestyle risk factors in HTx patients, and this group of patients should be screened for depressive symptoms.
No takes yet. Share an insight, caveat, or question.
Havik et al. (2007) conducted a cross-sectional in Heart Transplantation (n=147). Depressive symptoms (BDI ≥10) vs. No or minimal depressive symptoms was evaluated on All-cause mortality (RR 2.32, 95% CI 1.13-4.79, p=0.02). Depressive symptoms in heart transplant patients increased the risk of all-cause mortality over a minimum 5-year follow-up.
Synapse has enriched 10 related papers. Consider them for comparative context: