Key result
ACE inhibitors drive hypertension efficacy by inducing renal vasodilatation and increasing sodium excretion.
Population
Patients with essential hypertension, normal subjects, and patients with renal artery stenosis
Design
Review
Authors
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Highlights caution with ACE inhibitors in bilateral renal artery stenosis; leaves open the relative contribution of renal effects to efficacy.
The beneficial effects of ACE inhibitors on renal hemodynamics and sodium excretion play a key role in their efficacy for treating hypertension, though they carry a risk of renal failure in bilateral renal artery stenosis.
Norman K. Hollenberg (1985) conducted a review in Hypertension and renal artery stenosis. Angiotensin-Converting Enzyme Inhibition was evaluated. Angiotensin-converting enzyme inhibitors induce renal vasodilatation and increase sodium excretion, contributing substantially to their overall efficacy in the treatment of hypertension.
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