Key result
Among 29 Coxsackie virus strains, one Group A Type 2 strain exhibited unusual pathogenicity for chick embryos, and it along with 4 other strains grew readily in vitro on embryo chick tissue.
Population
29 strains of Coxsackie virus tested in embryonated eggs, and 16 strains tested in vitro on embryo chick…
Design
Preclinical
Authors
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Strain variability may guide Coxsackie virus culture selection; leaves open translation to human pathogenesis or diagnostics.
Strain differences are a primary factor in the adaptation of Coxsackie virus to growth in embryonated eggs or tissue culture.
Myrtle Shaw (1952) studied Coxsackie virus (n=29). Cultivation in embryonated eggs and chick tissue cultures was evaluated on Pathogenicity and growth in vitro. Among 29 Coxsackie virus strains, one Group A Type 2 strain exhibited unusual pathogenicity for chick embryos, and it along with 4 other strains grew readily in vitro on embryo chick tissue.
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