Key result
T. cruzi clone Sylvio-X10/7 produces acute lethal infection and shorter survival versus clone Sylvio-X10/4.
Population
C3H/HEN inbred mice
Comparison
Infection with Trypanosoma cruzi clone… vs Infection with Trypanosoma cruzi clone…
Design
Preclinical
Authors
Loading...
Findings from this mouse model should not change clinical practice; extends evidence that intra-strain T. cruzi genetic heterogeneity drives divergent infection phenotypes.
Demonstrates that genetic heterogeneity within a single Trypanosoma cruzi strain leads to different disease courses (acute lethal vs chronic) in an inbred mouse model.
Postan et al. (1983) studied Trypanosoma cruzi infection. Trypanosoma cruzi clone Sylvio-X10/7 vs. Trypanosoma cruzi clone Sylvio-X10/4 was evaluated on Course of infection (parasitemia, tissue involvement, survival time). Infection with T. cruzi clone Sylvio-X10/7 produced an acute lethal infection with higher parasitemia and shorter survival compared to the chronic infection produced by clone Sylvio-X10/4.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: