Key result
Triple infection with Trypanosoma cruzi clones exacerbated cardiac inflammatory lesions and increased IgM and IgG2a levels compared to single infection in mice.
Population
Mice evaluated during acute and chronic phases of Trypanosoma cruzi infection
Comparison
Triple infection with clones of the Colombian… vs Single infection with T. cruzi clones
Design
Preclinical
Follow-up
175 days
Authors
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Hypothesis-generating for T. cruzi strain diversity in Chagas models; leaves open human relevance and should not change practice.
Successive re-infections with different clones of T. cruzi exacerbate cardiac inflammatory lesions and alter humoral and cellular immune responses in a mouse model of Chagas disease.
Guerreiro et al. (2015) studied Trypanosoma cruzi infection (Chagas disease). Triple infection with clones of the Colombian strain of T. cruzi vs. Single infection was evaluated on Chronic myocarditis and humoral and cellular immune responses. Triple infection with Trypanosoma cruzi clones exacerbated cardiac inflammatory lesions and increased IgM and IgG2a levels compared to single infection in mice.
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