Key result
Successive reinfections with different strains of Trypanosoma cruzi in mice resulted in a significant exacerbation of cardiac and skeletal muscle inflammatory lesions.
Why the study?
Do successive reinfections with different strains of Trypanosoma cruzi exacerbate myocarditis and myositis in chronically infected mice?
Population
58 mice chronically infected with the Colombian strain (Biodeme Type III) of Trypanosoma cruzi
Design
Preclinical
Authors
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Reinfections may worsen Chagas cardiac lesions in mice; hypothesis-generating and leaves human relevance open.
Do successive reinfections with different strains of Trypanosoma cruzi exacerbate myocarditis and myositis in chronically infected mice?
Reinfections with different strains of Trypanosoma cruzi exacerbate cardiac and skeletal muscle inflammation in a mouse model of Chagas disease.
Andrade et al. (2006) studied Trypanosoma cruzi infection (Chagas' disease) (n=58). Successive reinfections with Trypanosoma cruzi strains of different biodemes was evaluated on Cardiac and skeletal muscle inflammatory lesions. Successive reinfections with different strains of Trypanosoma cruzi in mice resulted in a significant exacerbation of cardiac and skeletal muscle inflammatory lesions.
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