Key result
ADRA2B gene D allele linked to ~83% higher odds of essential hypertension.
Why the study?
Is the D allele of the ADRA2B gene associated with essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects?
Case-Control (n=210)
No
Is the D allele of the ADRA2B gene associated with essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects?
Odds Ratio: 0.545 (95% CI 0.388–0.837)
Absolute Event Rate: 67.14% vs 52.67%
p-value: p=0.012
The D allele of the ADRA2B gene is associated with an increased risk of essential hypertension, with or without type 2 diabetes, in the Malaysian population.
Should not yet change practice; hypothesis-generating for ADRA2B in Malaysians and requires prospective replication.
An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects with or without type 2 diabetes mellitus (T2DM). This study includes 70 hypertensive subjects without T2DM, 65 hypertensive subjects with T2DM and 75 healthy volunteers as control subjects. Genotyping of I/D polymorphism was performed by conventional PCR method. There was significant difference found in age, body mass index, systolic/diastolic blood pressure and high density lipoprotein cholesterol level between the case and control subjects. DD genotypic frequency of I/D polymorphism was significantly higher in hypertensive subjects (42.84% vs. 29.33%; P-=0.029) and in hypertensive with T2DM subjects (46.15% vs. 29.33%; P=0.046) than control group. D allele frequency was higher in hypertensive group (67.41%) than control subjects (52.67%). However, no significant difference was found between the three genotypes of I/D polymorphism of ADRA2B gene and the clinical characteristics of the subjects. The result obtained in this study show D allele of ADRA2B gene was associated with essential hypertension with or without T2DM in Malaysian subjects.
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Ismail et al. (2008) conducted a case-control in Essential hypertension with or without Type 2 Diabetes Mellitus (n=210). ADRA2B gene D allele / DD genotype vs. Healthy controls was evaluated on D allele frequency of the ADRA2B gene in hypertensive subjects vs controls (OR 0.545, 95% CI 0.388-0.837, p=0.012). The D allele of the ADRA2B gene was significantly associated with essential hypertension in Malaysian subjects, with a frequency of 67.14% in hypertensive patients compared to 52.67% in healthy controls.
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