Key result
Greater CAD severity correlates directly with higher LVEDP on both echo and catheterization.
Why the study?
Diastolic dysfunction from ischemia leads to heart failure and impacts hospitalization and mortality, but the correlation between LVEDP parameters and the severity of coronary artery involvement required investigation.
Does LVEDP correlate with the severity of coronary artery involvement in patients with coronary artery disease?
Cross-Sectional (n=90)
No
Does LVEDP correlate with the severity of coronary artery involvement in patients with coronary artery disease?
Effect estimate: R = 0.45 (echocardiography) and R = 0.50 (catheterization)
p-value: p=0.0001
LVEDP assessed non-invasively by echocardiography correlates significantly with the severity of coronary artery disease and invasive LVEDP measurements.
LVEDP by echocardiography may mark CAD severity; leaves open prospective validation before clinical adoption.
Background: Diastolic dysfunction due to ischemia leads to heart failure and significantly affects hospitalization rates and mortality. Non-invasive evaluation of left ventricular end-diastolic pressure (LVEDP) provides crucial data about left ventricular diastolic function. Objectives: This study aimed to investigate the correlation between the severity of coronary artery involvement and LVEDP parameters. Methods: In this descriptive study, 90 patients referred to Modarres Hospital with a diagnosis of coronary artery disease (CAD) were evaluated for LVEDP parameters using echocardiography and angiography. The presence and severity of CAD were determined by cardiac catheterization and the Gensini score. After collecting patient clinical data, the correlation between the Gensini score and LVEDP was examined. Results: The findings of the present study revealed a direct, weak, and significant correlation between LVEDP assessed by echocardiography and the Gensini score. There was also a significant, direct, and weak correlation between LVEDP assessed by angiography and the Gensini score. Additionally, a direct and strong correlation was observed between LVEDP assessed by echocardiography and angiography. Conclusions: The present study demonstrated that LVEDP is significantly associated with the severity and extent of CAD. The LVEDP can be assessed non-invasively by echocardiography before and after percutaneous coronary intervention (PCI) without additional complications, and can therefore be used to rapidly assess improvements in diastolic function.
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Safi et al. (2025) conducted a cross-sectional in Coronary Artery Disease (n=90). Severity of coronary artery disease (Gensini score) was evaluated on Correlation between LVEDP and Gensini score (R = 0.45 (echocardiography) and R = 0.50 (catheterization), p=0.0001). Coronary artery disease severity showed a significant direct correlation with left ventricular end-diastolic pressure assessed by echocardiography (R=0.45) and catheterization (R=0.50).
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