Key result
Sirolimus-eluting stents and bare-metal stents showed no significant overall differences in markers of platelet activation and coagulation in patients with stable CAD over 6 months.
Why the study?
Does sirolimus-eluting stent implantation affect long-term platelet activation and coagulation markers compared to bare-metal stent implantation in patients with stable coronary artery disease?
Population
47 consecutive patients aged <70 years with stable coronary artery disease and severe stenosis of one major…
Comparison
Sirolimus-eluting stent (SES) implantation (n=25) vs Bare-metal stent (BMS) implantation (n=22)
Design
RCT, Randomly allocated
Follow-up
6 months
Authors
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May guide stent selection independent of these markers in stable CAD; confirms transient activation resolves similarly by 6 months.
RCT (n=47)
randomly allocated
Does sirolimus-eluting stent implantation affect long-term platelet activation and coagulation markers compared to bare-metal stent implantation in patients with stable coronary artery disease?
Sirolimus-eluting stents and bare-metal stents demonstrate similar long-term profiles regarding platelet activation and coagulation markers in stable CAD patients, with transient post-procedural increases resolving by 6 months.
Marketou et al. (2017) conducted an RCT in stable coronary artery disease (n=47). Sirolimus-eluting stents (SES) vs. Bare-metal stent (BMS) was evaluated on Plasma levels of sP-selectin, von Willebrand Factor (vWF), fibrinogen, d-dimer, sCD40, factor VIII, b-thromboglobulin (b-TG) and platelet factor 4 (PF-4). Sirolimus-eluting stents and bare-metal stents showed no significant overall differences in markers of platelet activation and coagulation in patients with stable CAD over 6 months.
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