Key result
Dilated cardiomyopathy is linked to ~49% lower vitamin D levels versus matched controls.
Why the study?
Are lower Vitamin D levels associated with dilated cardiomyopathy and worse echocardiographic parameters?
Case-Control (n=116)
No
Are lower Vitamin D levels associated with dilated cardiomyopathy and worse echocardiographic parameters?
Patients with dilated cardiomyopathy have a higher prevalence of severe Vitamin D deficiency, which correlates negatively with left ventricular dimensions.
Supports vitamin D assessment in dilated cardiomyopathy; hypothesis-generating for supplementation trials before practice change.
BACKGROUND/INTRODUCTION: Recent studies have indicated a much broader role to Vitamin D than simply the regulation of calcium metabolism alone. Vitamin D likely confers physiologically relevant pleiotropic functions that include cardioprotective and immunomodulatory effect, and its deficiency could lead to increased risk of cardiovascular disease and heart failure. AIM: The aim of our work was to evaluate the presence of hypovitaminosis D in patients with dilated cardiomyopathy (DCMP) and to study any correlation of echocardiographic parameters with Vitamin D deficiency. PATIENTS AND METHODS: In an observational case-control hospital-based study, 56 patients diagnosed to have DCMP and 60 age-, gender-, and body mass index-matched controls who were patients of other medical illnesses were included in the study. Each subject underwent transthoracic two-dimensional guided M-mode echocardiography, and Vitamin D, parathyroid hormone (PTH), and N-terminal pro-B-type natriuretic peptide (NT-ProBNP) were assessed. In DCMP group, 24/56 patients had severe Vitamin D deficiency, whereas in control group, 10/60 patients had severe hypovitaminosis D. There was a significant negative correlation between 25(OH) D3 concentrations and left ventricular (LV) end-diastolic and LV end-systolic dimensions. CONCLUSION: Patients with DCMP had lower Vitamin D levels than controls, and Vitamin D deficiency had a significant correlation with cardiac function. Therefore, screening for Vitamin D deficiency along with prompt treatment is recommended in patients with DCMP.
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Karoli et al. (2016) conducted a case-control in Dilated cardiomyopathy (n=116). Dilated cardiomyopathy vs. Matched controls was evaluated on Mean 25-hydroxyvitamin D3 levels (p=0.001). Patients with dilated cardiomyopathy had significantly lower mean 25-hydroxyvitamin D3 levels compared to matched controls (14.5 vs. 28.2 ng/ml, p=0.001).
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