July 1, 1992Journal of Hypertension
Blood rheology in arterial hypertension
Key result
Hypertension-associated hyperviscosity correlates with higher BP, disease severity, and LVH.
Population
Patients with arterial hypertension
Design
Review
Authors
Discussion
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Implication
Hyperviscosity may worsen hypertensive complications; leaves open whether rheological effects of antihypertensives improve outcomes without controlled trials.
Structured PICO
P
Population
Patients with arterial hypertension
E
Exposure
Antihypertensive agents
O
Outcome
Blood rheology variables (hyperviscosity)surrogate
Blood hyperviscosity in hypertension is associated with worse prognosis and complications, but the clinical relevance of antihypertensive effects on rheology requires further controlled studies.
Limitations
- Most studies that have investigated the effects of therapy on rheological variables have not been performed in clinically relevant situations.
- Most studies investigating the effects of therapy on rheological variables have not been performed in clinically relevant situations
- Mechanisms of haemorheological abnormalities in hypertension are still unclear
Cite This Study
Zannad et al. (1992) conducted a review in Arterial hypertension. Blood rheology abnormalities was evaluated. Blood rheology abnormalities in arterial hypertension create a hyperviscosity state that correlates with blood pressure levels, disease severity, and complications such as left ventricular hypertrophy.