Key result
In a porcine model, endotoxemia significantly reduced the correlation between regional myocardial O2 delivery and O2 uptake compared to controls (r=0.18 vs r=0.73, P=0.009).
Absolute Event Rate: 0.18% vs 0.73%
p-value: p=0.009
Endotoxemia causes a redistribution of LV regional coronary blood flow and a mismatch between regional O2 delivery and demand, which may contribute to myocardial depression in sepsis.
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Endotoxemia disrupts myocardial O2 matching in porcine sepsis models; hypothesis-generating and requires human validation before clinical relevance.
Alders et al. (2011) studied Endotoxemia / Sepsis (n=13). Endotoxemia vs. Controls was evaluated on Correlation of regional O2 delivery to O2 uptake (p=0.009). In a porcine model, endotoxemia significantly reduced the correlation between regional myocardial O2 delivery and O2 uptake compared to controls (r=0.18 vs r=0.73, P=0.009).
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