Key result
Two young siblings with Influenza A(H1N1)pdm09 infection and RANBP2 gene mutations developed acute necrotizing encephalopathy, leading to critical illness, one recovery, and one death.
Population
Two young siblings with Influenza Apdm09 virus infection and RANBP2 gene mutations who developed acute…
Design
Case_report
Follow-up
11 days to 2 weeks
Authors
Loading...
May warrant vigilance for ANE in RANBP2 carriers with influenza; leaves open genetic screening or targeted prevention strategies.
Case Report (n=2)
Influenza-associated acute necrotizing encephalopathy can be fatal, particularly in children with RANBP2 gene mutations, highlighting the importance of annual influenza vaccination.
Howard et al. (2018) conducted a case report in Influenza-Associated Acute Necrotizing Encephalopathy (n=2). Influenza A(H1N1)pdm09 virus infection was evaluated on Clinical outcome. Two young siblings with Influenza A(H1N1)pdm09 infection and RANBP2 gene mutations developed acute necrotizing encephalopathy, leading to critical illness, one recovery, and one death.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: