What question did this study set out to answer?

To review the biochemistry, genetics, and pathogenic roles of bacterial ureases and urea metabolism in major ureolytic species that cause human disease.

April 1, 2000Microbes and InfectionOpen Access

Bacterial ureases in infectious diseases

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Authors

RBRobert A. BurneUtah State University YCYi‐Ywan M. ChenChang Gung University

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Implication

Narrative review outlines bacterial urease mechanisms in human pathogens, highlighting urea metabolism as a key driver of microbial ecology and virulence.

Key Points

To review the biochemistry, genetics, and pathogenic roles of bacterial ureases and urea metabolism in major ureolytic species that cause human disease.
Literature review of biochemical and genetic characteristics of nickel-dependent bacterial urease complexes.
Synthesis of evidence regarding microbial ecology and mechanisms of urease-mediated pathogenesis in human infections.
Bacterial ureases function as multi-subunit, nickel-containing metalloenzymes that catalyze the hydrolysis of urea into ammonia and carbon dioxide.
Ureolytic activity enables acid tolerance and ecological adaptation, serving as a primary virulence factor across major human pathogenic species.

Cite This Study

Burne et al. (2000) studied this question.

synapsesocial.com/papers/6aa23dac778c15cc5446f337 https://doi.org/10.1016/s1286-4579(00)00312-9

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Implication

Narrative review outlines bacterial urease mechanisms in human pathogens, highlighting urea metabolism as a key driver of microbial ecology and virulence.

Bacterial ureases in infectious diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Bacterial ureases in infectious diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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