Key result
Changing from a supine to an upright body position significantly increased the QTc interval by an average of 18 ms and caused T-wave inversions in 14.7% of patients.
Why the study?
Does upright body position compared to supine position alter ECG repolarization characteristics in patients?
Cross-Sectional (n=1,028)
Single-blind
No
Does upright body position compared to supine position alter ECG repolarization characteristics in patients?
Mean Difference: 18
Absolute Event Rate: 444% vs 426%
p-value: p=<0.001
Assessment of the QTc interval should strictly be done in a supine position to avoid overestimation caused by upright posture.
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Upright position was associated with QTc overestimation; leaves open whether routine supine assessment improves arrhythmia risk stratification.
Markendorf et al. (2017) conducted a cross-sectional in Various cardiologic and non-cardiologic diagnoses (n=1,028). Upright body position vs. Supine body position was evaluated on QTc interval (Bazett's formula) (MD 18.00, p=<0.001). Changing from a supine to an upright body position significantly increased the QTc interval by an average of 18 ms and caused T-wave inversions in 14.7% of patients.
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