Key result
Posture change to supine decreased plasma vasopressin from 0.9 to 0.5 pg/ml (P<0.05), but this suppression was absent when lower body negative pressure prevented increases in left atrial diameter.
Why the study?
Does preventing increases in left atrial diameter and pulse pressure using lower body negative pressure prevent the suppression of vasopressin release during antiorthostatic posture change in healthy males?
Population
10 healthy males
Comparison
Posture change from upright seated with legs… vs Posture change to supine without LBNP
Design
Other
Follow-up
30 min
Authors
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Left atrial distension may suppress vasopressin via baroreflexes in healthy males; leaves open relevance to clinical orthostasis or volume disorders.
Does preventing increases in left atrial diameter and pulse pressure using lower body negative pressure prevent the suppression of vasopressin release during antiorthostatic posture change in healthy males?
p-value: p=<0.05
Suppression of vasopressin secretion during antiorthostatic posture change is critically dependent on increases in arterial pulse pressure and/or left atrial diameter.
Pump et al. (1999) studied Healthy (n=10). Posture change to supine with lower body negative pressure (LBNP) vs. Posture change to supine without LBNP was evaluated on Plasma arginine vasopressin (AVP) concentration (p=<0.05). Posture change to supine decreased plasma vasopressin from 0.9 to 0.5 pg/ml (P<0.05), but this suppression was absent when lower body negative pressure prevented increases in left atrial diameter.
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