Key result
Levobupivacaine scalp block cuts additional propofol use ~64% vs ropivacaine, improving overall hemodynamic stability.
Why the study?
Maintaining good intraoperative haemodynamic stability during neuroanaesthesia is challenging, and the comparative efficacy of ropivacaine versus levobupivacaine scalp blocks for stability and additional analgesia requirements needed evaluation.
Does Ropivacaine compared to Levobupivacaine improve intraoperative hemodynamic stability and reduce the requirement of additional analgesia in patients undergoing elective supratentorial craniotomy?
RCT (n=60)
computerised program
No
Does Ropivacaine compared to Levobupivacaine improve intraoperative hemodynamic stability and reduce the requirement of additional analgesia in patients undergoing elective supratentorial craniotomy?
Absolute Event Rate: 16.7% vs 46.7%
p-value: p=0.04
Levobupivacaine provides better overall efficacy and hemodynamic stability compared to Ropivacaine when used for scalp block in supratentorial craniotomy.
Supports levobupivacaine over ropivacaine for scalp block in supratentorial craniotomy; extends RCT data guiding local anesthetic selection.
Background: Neuroanaesthesia is very challenging as maintaining good haemodynamic stability intraoperatively is important.Scalp block can be an effective measure in providing good peri-operative haemodynamic stability and favourable postoperative neurological profile for assessment.Aim: To compare the efficacy of isobaric 0.5% Ropivacaine with isobaric 0.5% Levobupivacaine when used for scalp block in terms of intraoperative haemodynamic stability and requirement of additional analgesia and anaesthetics intraoperatively.Methods: 60 patients of either sex, aged between 18 to 60 years, ASA grade I and II undergoing elective supratentorial craniotomy under General Anaesthesia (GA) were randomly divided into 2 groups.Group B was given scalp block with isobaric 0.5% Levobupivacaine whereas Group R with isobaric 0.5% Ropivacaine.Scalp block was performed after standard GA induction using Modified Pinosky technique.Intraoperative surges in heart rate (HR) or systolic blood pressure (SBP) were noted in response to skull pin insertion and scalp incision.Overall haemodynamic stability and total requirement of additional analgesia and anaesthetics intraoperatively were noted.Results: The response to pin insertion was obtunded by both Ropivacaine and Levobupivacaine but overall, the response to pin insertion concerning mean HR was better in Group B than Group R. The response to incision was blunted in both the groups but was better in Group R. The requirement of additional analgesia and anaesthetic was higher in Group R than Group B and therefore, hemodynamic stability also appears to be better in Group R.Conclusion: Ropivacaine and Levobupivacaine (20 ml of isobaric 0.5% conc.) when used for scalp block, were both effective in preventing sympathetic response to skull pin insertion and incision.However, overall Levobupivacaine has better efficacy.
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Deshmukh et al. (2020) conducted an RCT in Intracranial space-occupying lesion requiring supratentorial craniotomy (n=60). Levobupivacaine scalp block vs. Ropivacaine scalp block (20 ml of isobaric 0.5% concentration) was evaluated on Requirement of additional intraoperative propofol for hemodynamic control (p=0.04). Levobupivacaine scalp block significantly reduced the intraoperative requirement for additional propofol compared to ropivacaine (16.7% vs 46.7%, p=0.04) while providing better overall hemodynamic stability during supratentorial craniotomy.
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