Key result
High hyper-acute adrenaline and noradrenaline levels strongly predict poor outcomes in aneurysmal subarachnoid hemorrhage.
Why the study?
Do acute catecholamine levels predict patient outcome and delayed vasospasm in patients with aneurysmal subarachnoid hemorrhage?
Population
170 patients with aneurysmal subarachnoid hemorrhage (SAH)
Design
Cohort
Authors
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May aid early prognostication in hyperacute aSAH; hypothesis-generating for catecholamine-targeted trials.
Observational (n=170)
Do acute catecholamine levels predict patient outcome and delayed vasospasm in patients with aneurysmal subarachnoid hemorrhage?
Effect estimate: ROC area 0.83
Sympathetic activation in the acute phase of aneurysmal subarachnoid hemorrhage reflects disease severity and is a strong predictor of both poor patient outcome and the development of delayed vasospasm.
Ogura et al. (2012) conducted an observational in aneurysmal subarachnoid hemorrhage (SAH) (n=170). Acute catecholamine surge (plasma adrenaline, noradrenaline, and dopamine) was evaluated on Poor patient outcome (ROC area 0.83). High plasma adrenaline and noradrenaline levels at the hyper-acute phase of aneurysmal subarachnoid hemorrhage were strong predictors of poor patient outcome (ROC area 0.83).
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