Key result
Stress shifts DRBD3 to the nucleus or stress granules in Trypanosoma brucei while preserving mRNA binding.
In Trypanosoma brucei, the RNA-binding protein DRBD3 alters its subcellular localization and protein complex composition in response to environmental stress while remaining bound to target mRNAs.
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No immediate clinical implications for trypanosomiasis; leaves open DRBD3 as a target in parasite mRNA regulation.
Fernández‐Moya et al. (2012) studied Trypanosoma brucei biology. Cellular stress (oxidative challenge or starvation) vs. Unstressed cells was evaluated on Alterations in DRBD3 subcellular localization and ribonucleoprotein complex composition. In Trypanosoma brucei, the RNA-binding protein DRBD3 translocates from the cytoplasm to the nucleus upon oxidative stress and to stress granules during starvation, while remaining bound to target mRNAs.
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