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July 8, 2008Nucleic Acids ResearchOpen Access

The RNA-binding protein Tb DRBD3 regulates the stability of a specific subset of mRNAs in trypanosomes

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Key result

TbDRBD3 binds to a subset of developmentally regulated mRNAs encoding membrane proteins, promoting the stabilization of the target transcripts in trypanosomes.

Population

Trypanosomes

Design

Preclinical

Authors

AEAntonio M. EstévezInstituto de Parasitología y Biomedicina "López - Neyra"

Discussion

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Implication

Hypothesis-generating for post-transcriptional operons in trypanosomes; leaves open therapeutic targeting in parasitic disease.

Structured PICO

P
Population
Trypanosomes
I
Intervention
RNA interference, microarray analysis, and immunoprecipitation of mRNA-protein complexes targeting TbDRBD3
O
Outcome
Function of TbDRBD3 and its effect on mRNA abundance and translationsurrogate

TbDRBD3-mRNA complexes may act as a post-transcriptional operon, providing a mechanism for trypanosomes to regulate gene expression without transcriptional control.

Cite This Study

Antonio M. Estévez (2008) studied Trypanosome gene expression. TbDRBD3 was evaluated on mRNA stability and translation regulation. TbDRBD3 binds to a subset of developmentally regulated mRNAs encoding membrane proteins, promoting the stabilization of the target transcripts in trypanosomes.

synapsesocial.com/papers/6a9ed1d43bd0b4e8cb716e9fhttps://doi.org/10.1093/nar/gkn406
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DEVELOPMENTAL CYCLES AND BIOLOGY OF PATHOGENIC TRYPANOSOMES1985 · 631 citations
  2. 2Continuous Cultivation of Trypanosoma brucei Blood Stream Forms in a Medium Containing a Low Concentration of Serum Protein without Feeder Cell Layers1989 · 1,058 citations
  3. 3cAMP Signalling in the Kinetoplastid Protozoa2004 · 53 citations
  4. 4Evolution of nuclear ribosomal RNAs in kinetoplastid protozoa: perspectives on the age and origins of parasitism.1993 · 237 citations