Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity

Sekar et al. (2007) studied this question. Lentiviral vectors encoding eGFP or Kir2.1 vs. LVs encoding LacZ or devoid of a transgene was evaluated on Cytotoxicity and electrophysiological alterations (conduction velocity and action potential duration). Transduction of neonatal rat ventricular myocytes with lentiviral vectors encoding eGFP decreased conduction velocity and action potential duration without inducing cytotoxicity.