Key result
Extradural anaesthesia shows no difference versus general anaesthesia in thrombin generation or fibrinolysis during knee arthroplasty.
Why the study?
Does extradural anaesthesia compared to general anaesthesia alter thrombin generation or fibrinolytic activity in patients undergoing total knee arthroplasty?
Population
31 patients undergoing primary unilateral total knee arthroplasty performed under tourniquet
Comparison
Extradural anaesthesia vs General anaesthesia
Design
RCT, allocated randomly
Follow-up
perioperative period
Authors
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Extradural anaesthesia confers no haemostatic advantage over general anaesthesia in tourniquet knee arthroplasty; confirms equivalent effects on perioperative thrombin generation and fibrinolysis.
RCT (n=31)
Randomly allocated
Does extradural anaesthesia compared to general anaesthesia alter thrombin generation or fibrinolytic activity in patients undergoing total knee arthroplasty?
The type of anaesthesia (extradural vs general) does not significantly influence perioperative thrombin generation or fibrinolytic activity during total knee arthroplasty under tourniquet.
Sharrock et al. (1997) conducted an RCT in Primary unilateral total knee arthroplasty (n=31). Extradural anaesthesia vs. General anaesthesia was evaluated on Markers of thrombin generation and fibrinolysis. Extradural and general anaesthesia did not result in significant differences in either thrombin generation or fibrinolytic activity during total knee arthroplasty performed under tourniquet.
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