Key result
Alimentary obesity does not impair RV capillarization under chronic hypoxia in mice.
Why the study?
To test whether alterations of the RV capillary network under chronic hypoxia-induced pulmonary hypertension are aggravated by alimentary obesity, predisposing to subsequent RV dysfunction.
Does alimentary obesity aggravate chronic hypoxia-induced alterations of the right ventricular capillary network in mice?
Does alimentary obesity aggravate chronic hypoxia-induced alterations of the right ventricular capillary network in mice?
Alimentary obesity does not aggravate right ventricular capillary network alterations in a mouse model of chronic hypoxia-induced pulmonary hypertension.
Obesity may aggravate RV capillary rarefaction in hypoxic PH; hypothesis-generating in Level 5 models, clinical relevance remains open.
BACKGROUND AND AIMS: Obesity is a risk factor of cardiopulmonary disorders including left and right ventricular dysfunction and pulmonary hypertension (PH), and PH is associated with right ventricular (RV) hypertrophy and failure. Here, we tested the hypothesis that alterations of the RV capillary network under PH induced by chronic hypoxia are aggravated by alimentary obesity, thereby representing a predisposition for subsequent RV dysfunction. METHODS AND RESULTS: ) during the last 3 weeks of the experiments. Hearts were prepared for light and electron microscopy and right atria and RVs were analyzed by design-based stereology. HFD and hypoxia independently increased RV and cardiomyocyte volume. These changes were further enhanced in HFD-Hyp. The ratio between RV and body weights was similar in CD and HFD but enhanced in both hypoxia groups to a similar extent. The total length of capillaries was elevated in proportion with the RV hypertrophy, thus the area of myocardium supplied by an average capillary was similar in all groups. Similarly, the thickness of the capillary endothelium was not altered by HFD or hypoxia. CONCLUSION: In conclusion, in experimental PH capillaries of the RV myocardium showed similar adaptations in lean and obese mice. Thus, under chronic hypoxic conditions, obesity had no adverse effect on the capillarization of the right ventricle.
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Mühlfeld et al. (2023) studied Pulmonary hypertension and right ventricular hypertrophy. Alimentary obesity (High-fat diet) vs. Control diet (lean mice) was evaluated on Alterations of the right ventricular capillary network (total length, area supplied, endothelium thickness). Under chronic hypoxic conditions, alimentary obesity had no adverse effect on the capillarization of the right ventricle in mice.
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