Key result
Calcific aortic stenosis represents an active disease process rather than simple age-related degeneration.
Highlights that calcific aortic stenosis is an active disease process rather than simply a degenerative condition associated with aging.
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May stimulate targeted therapy research in aortic stenosis; leaves open any change to current clinical management.
Over the past 15 years, the increasing use of echocardiography has dramatically changed our understanding of the prevalence and progression of aortic-valve stenosis. Aortic stenosis may be due to rheumatic disease or to calcification of a congenitally bicuspid or normal trileaflet valve. However, in the United States and Europe, calcific valvular disease is by far the most common cause of aortic stenosis.We now recognize that calcific valvular disease is not simply a degenerative condition associated with aging but, instead, represents the end stage of an active disease process. In the early stages, the aortic side of the valve contains . . .
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Catherine M Otto (2000) conducted a review in Aortic Stenosis. Calcific aortic stenosis is recognized as an active disease process rather than a simple degenerative condition associated with aging.
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