Key result
New RP-HPLC method successfully quantifies Argatroban Intermediate and its related substances.
A simple and specific RP-HPLC method was successfully developed and validated for the quantitative analysis of Argatroban Intermediate and its impurities.
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New validated RP-HPLC method aids argatroban impurity analysis; leaves open any clinical or manufacturing adoption pending further study.
Wang et al. (2023) studied this question. Reversed-phase high performance liquid chromatography (RP-HPLC) method was evaluated on Method validation parameters (linearity, LOD, LOQ, precision, accuracy). A new reversed-phase high performance liquid chromatography method was successfully developed and validated for the quantitative analysis of Argatroban Intermediate and its six related substances.