Key result
A modified HPLC method successfully quantified argatroban and its M1-metabolite simultaneously, revealing mean steady infusion concentrations of 0.7 +/- 0.35 and 5.5 +/- 2.8 microgram/mL, respectively.
A newly developed HPLC method allows for the simultaneous and differential quantitation of argatroban and its M1-metabolite, providing a rapid assessment of its pharmacokinetics and pharmacodynamics.
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New HPLC method distinguishes argatroban from M1; extends monitoring options but leaves clinical adoption open pending validation.
Ahmad et al. (1999) studied Heparin-induced thrombocytopenia (n=30). HPLC method for simultaneous quantitation of argatroban and M1-metabolite was evaluated on Concentration of argatroban and M1-metabolite. A modified HPLC method successfully quantified argatroban and its M1-metabolite simultaneously, revealing mean steady infusion concentrations of 0.7 +/- 0.35 and 5.5 +/- 2.8 microgram/mL, respectively.
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