Key result
Lowest plasma CETP quartile predicts ~220% more cardiovascular events than the highest in pravastatin-treated CAD.
Why the study?
Do plasma CETP concentrations predict cardiovascular events in hypercholesterolaemic patients with CAD treated with pravastatin?
Population
1389 hypercholesterolaemic men and women with preexisting coronary artery disease (CAD)
Comparison
Pravastatin treatment with high plasma CETP… vs Pravastatin treatment with low plasma CETP…
Design
Cohort
Follow-up
2 years
Authors
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Low CETP levels were associated with higher event rates on pravastatin; hypothesis-generating for CETP as a prognostic marker in CAD.
Observational (n=1,389)
Yes
Do plasma CETP concentrations predict cardiovascular events in hypercholesterolaemic patients with CAD treated with pravastatin?
Odds Ratio: 3.2 (95% CI 1.65–6.23)
p-value: p=0.001
High plasma CETP concentrations at baseline predict fewer cardiovascular events in CAD patients treated with pravastatin, despite higher LDL cholesterol concentrations.
Marschang et al. (2006) conducted an observational in Coronary artery disease (CAD) (n=1,389). Lowest quartile of plasma CETP concentrations vs. Highest quartile of plasma CETP concentrations was evaluated on Cardiovascular events (OR 3.20, 95% CI 1.65-6.23, p=0.001). The lowest quartile of plasma CETP concentrations predicted more cardiovascular events than the highest quartile in pravastatin-treated CAD patients (OR 3.20; 95% CI 1.65-6.23; P=0.001).
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