CETP gene variation: relation to lipid parameters and cardiovascular risk

S. Matthijs Boekholdt; J.A. Kuivenhoven; G. Kees Hovingh; J. Wouter Jukema; John J.P. Kastelein; Arie van Tol

doi:10.1097/01.mol.0000137226.54278.60

July 8, 2004Current Opinion in Lipidology

CETP gene variation: relation to lipid parameters and cardiovascular risk

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Key Points

To review evidence on how natural variations in the CETP gene affect lipid parameters, lipoprotein particle size, cardiovascular risk, and responsiveness to pravastatin therapy.
Synthesized findings from promoter region haplotype analyses and meta-analyses investigating CETP variants, including -629 C-->A, TaqIB, and I405V.
Evaluated pharmacogenetic subanalyses from large randomized controlled pravastatin trials assessing gene-drug interactions.
Haplotype analysis confirmed that the -629 C-->A promoter variant, rather than TaqIB, directly modulates CETP activity, whereas meta-analyses confirmed I405V and TaqIB associate with reduced CETP activity and increased HDL cholesterol.
CETP genetic variants correlate with altered plasma CETP levels, higher HDL cholesterol, modified LDL and HDL particle sizes, and potentially reduced risk of coronary artery disease.
Subanalyses of large randomized controlled trials showed no evidence of a pharmacogenetic interaction between the CETP TaqIB variant and pravastatin efficacy.

Implication

Review demonstrates altered lipid profiles across CETP genetic variants, indicating that targeted CETP inhibition may modify cardiovascular risk independent of statin efficacy.

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Cite This Study

Boekholdt et al. (2004) studied this question.

synapsesocial.com/papers/6ab4e4135164e086c6f64df3 https://doi.org/10.1097/01.mol.0000137226.54278.60

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CETP gene variation: relation to lipid parameters and cardiovascular risk

Key Points

Implication

Abstract

Discussion

Cite This Study

CETP gene variation: relation to lipid parameters and cardiovascular risk

Key Points

Implication

Abstract

Discussion

Cite This Study

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