Key result
A genetic score of CETP variants associated with increased HDL-C was strongly associated with an increased risk of intracerebral hemorrhage (OR 1.86, P=1.39x10^-6).
Why the study?
Do genetic variants in CETP that increase HDL-C increase the risk of intracerebral hemorrhage?
Population
2,774 intracerebral hemorrhage cases and 3,083 controls, including patients of European ancestry.
Comparison
CETP DNA sequence variants associated with… vs Absence of these CETP variants or lower genetic…
Design
Case-control
Authors
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May signal ICH risk with CETP inhibitors; hypothesis-generating and requires prospective validation.
Case-Control (n=5,857)
Yes
Do genetic variants in CETP that increase HDL-C increase the risk of intracerebral hemorrhage?
Odds Ratio: 1.86
p-value: p=1.39 × 10−6
Genetic variants in CETP that increase HDL-C are associated with a significantly higher risk of intracerebral hemorrhage, suggesting potential cerebrovascular safety risks for CETP inhibitors in clinical development.
Anderson et al. (2016) conducted a case-control in Intracerebral hemorrhage (n=5,857). CETP DNA sequence variants associated with higher HDL-C vs. Absence of variants / Controls was evaluated on Intracerebral hemorrhage (OR 1.86, p=1.39 × 10−6). A genetic score of CETP variants associated with increased HDL-C was strongly associated with an increased risk of intracerebral hemorrhage (OR 1.86, P=1.39x10^-6).
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