Over-the-Counter Naproxen Sodium and Esophageal Injury

Letters15 June 1997Over-the-Counter Naproxen Sodium and Esophageal InjuryLaura H. Kahn, MD, MPH, Min Chen, MS, RPh, and Robert Eaton, RPhLaura H. Kahn, MD, MPHU.S. Food and Drug Administration, Rockville, MD 20857Search for more papers by this author, Min Chen, MS, RPhU.S. Food and Drug Administration, Rockville, MD 20857Search for more papers by this author, and Robert Eaton, RPhU.S. Food and Drug Administration, Rockville, MD 20857Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-12-199706150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We report a case series involving predominantly young, healthy persons who developed esophageal problems after consuming over-the-counter naproxen sodium. This drug (at a dose of 220 mg) was approved for marketing in January 1994. The U.S. Food and Drug Administration's Spontaneous Reporting System received 81 reports of esophageal symptoms occurring with the drug; these cases made up approximately 1% of all reports for over-the-counter naproxen sodium received through December 1995.The mean patient age in our series was 35.9 years, and 65 patients (80%) were women. Intake of the tablet (as opposed to the caplet) form was ...References1. Marvola M, Rajaniemi M, Marttila E, Yahervuo K, Sothmann A. Effect of dosage form and formulation factors on the adherence of drugs to the esophagus. J Pharm Sci. 1983; 72:1034-6. Google Scholar2. Kikendall JW. Pill-induced esophageal injury. Gastroenterol Clin North Am. 1991; 20:835-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Laura H. Kahn, MD, MPH; Min Chen, MS, RPh; Robert Eaton, RPhAffiliations: U.S. Food and Drug Administration, Rockville, MD 20857Disclaimer: Opinions and assertions contained herein are those of the authors and are not to be construed as representing those of the U.S. Food and Drug Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedication‐Induced Esophageal InjuryNaproxen and piproxenPill‐Induced Esophageal InjuryEsophageal Disorders Caused by Medications, Trauma, and InfectionDrug-Induced Esophageal Injuries and DysphagiaSubsequent Loss of The Proliferated Bile Ductules in Fulminant Hepatitis in Childhood—Isnʼt It Caused by Apoptosis?Saure antipyretische AnalgetikaNSAIDs, Aspirin, and Esophageal StricturesPill EsophagitisAnti-inflammatory and antipyretic analgesics and drugs used in gout 15 June 1997Volume 126, Issue 12Page: 1006KeywordsAntiviralsCase seriesDrugsEndoscopyFood and Drug AdministrationHemorrhageIbuprofenPharynxSodiumUlcers ePublished: 15 August 2000 Issue Published: 15 June 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...