Key result
Systemic inflammatory disease links to ~95% higher long-term mortality in young adults after first MI.
Why the study?
Data are limited regarding the prevalence and prognostic effects of autoimmune systemic inflammatory diseases among adults who experience an MI at a young age.
Does the presence of systemic inflammatory disease increase the risk of all-cause mortality in young adults who experienced a first MI?
Population
2097 patients who experienced a first MI at 50 years of age or younger
Comparison
Patients with SID vs non-SID patients
Design
Retrospective cohort study from two large academic centres
Follow-up
Median 11.2 years
Authors
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Supports closer post-MI surveillance in young adults with systemic inflammation; leaves open whether targeted therapies improve survival.
Cohort (n=2,097)
Yes
Does the presence of systemic inflammatory disease increase the risk of all-cause mortality in young adults who experienced a first MI?
Hazard Ratio: 1.95 (95% CI 1.07–3.57)
Absolute Event Rate: 20.8% vs 11.9%
p-value: p=0.030
Among young adults experiencing a first MI, the presence of systemic inflammatory disease is associated with significantly worse long-term survival.
Weber et al. (2021) conducted a cohort in Myocardial infarction (n=2,097). Systemic inflammatory disease vs. No systemic inflammatory disease was evaluated on All-cause mortality (HR 1.95, 95% CI 1.07-3.57, p=0.030). Among young adults who experienced a first myocardial infarction, the presence of systemic inflammatory disease was associated with a significantly higher risk of long-term all-cause mortality (HR 1.95).
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