Key result
Recurrent Graves hyperthyroidism linked to recurrent Takotsubo cardiomyopathy, with LV recovery following thyroid normalization.
Case Report (n=1)
This case report suggests a possible role of thyroid-hormone excess in the pathophysiology of takotsubo cardiomyopathy, as LV function normalized following the resolution of thyrotoxicosis.
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Hypothesis-generating link between Graves hyperthyroidism and recurrent Takotsubo; should not change practice without prospective confirmation.
Takotsubo cardiomyopathy, or transient left ventricular apical ballooning syndrome, is characterized by acute left ventricular dysfunction caused by transient wall-motion abnormalities of the left ventricular apex and mid ventricle in the absence of obstructive coronary artery disease. Recurrent episodes are rare but have been reported, and several cases of takotsubo cardiomyopathy have been described in the presence of hyperthyroidism. We report the case of a 55-year-old woman who had recurrent takotsubo cardiomyopathy, documented by repeat coronary angiography and evaluations of left ventricular function, in the presence of recurrent hyperthyroidism related to Graves disease. After both episodes, the patient's left ventricular function returned to normal when her thyroid function normalized. These findings suggest a possible role of thyroid-hormone excess in the pathophysiology of some patients who have takotsubo cardiomyopathy.
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Patel et al. (2016) conducted a case report in Takotsubo cardiomyopathy and hyperthyroidism (n=1). Hyperthyroidism was evaluated on Recurrent Takotsubo cardiomyopathy. Recurrent hyperthyroidism related to Graves disease was associated with recurrent Takotsubo cardiomyopathy, with left ventricular function returning to normal when thyroid function normalized.
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