Key result
Thyrotoxicosis from toxic multinodular goiter linked to takotsubo cardiomyopathy, suggesting direct thyroid hormone effects.
Why the study?
An association between takotsubo cardiomyopathy and thyroid disease has been identified mostly in Grave disease, but its relation to toxic multinodular goiter was previously unreported.
Case Report (n=1)
This case report highlights that thyroid disease, specifically thyrotoxicosis from toxic multinodular goiter, should be considered in patients presenting with takotsubo cardiomyopathy.
May warrant thyroid evaluation in takotsubo cardiomyopathy; single case leaves open generalizability and causality.
Takotsubo cardiomyopathy is increasingly recognized as a distinct clinical entity. An association with thyroid disease has been identified in several case reports, mostly in the context of Grave disease. We report the case of a 67-year-old woman presenting with takotsubo cardiomyopathy and thyrotoxicosis secondary to toxic multinodular goiter. Previously unreported, this suggests that this association is related to the direct effects of thyroid hormone, rather than an autoimmune mechanism. Thyroid disease should be considered in patients presenting with takotsubo cardiomyopathy.
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O’Callaghan et al. (2015) conducted a case report in Takotsubo cardiomyopathy and thyrotoxicosis secondary to toxic multinodular goiter (n=1). Primary hyperthyroidism secondary to toxic multinodular goiter was evaluated. A 67-year-old woman developed takotsubo cardiomyopathy associated with thyrotoxicosis secondary to toxic multinodular goiter, suggesting a direct effect of thyroid hormone.
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