Key result
Injection of radioactive electrolytes in canine heart-lung preparations showed that a fraction moves out of the blood and partially returns, altering dilution curves and cardiac output calculations.
Population
Canine heart-lung preparation
Design
Preclinical
Authors
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Alerts to inaccuracies in electrolyte-based dilution cardiac output estimates; leaves open optimal tracer selection for hemodynamic research.
The use of radioactive electrolytes for the Stewart-Hamilton method is confounded by their diffusion out of and back into the blood during pulmonary transit.
David L. Yudilevich (1961) studied this question. Injection of K 42+, Na 24+, and I 131+ tracers vs. Nondiffusible Risa was evaluated on Transport of radioactive electrolytes and alteration of dilution curves. Injection of radioactive electrolytes in canine heart-lung preparations showed that a fraction moves out of the blood and partially returns, altering dilution curves and cardiac output calculations.
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