Key result
Experimental acute myocardial infarction involving the left ventricle induced a significant 33% decline in right ventricular fractional area change in the absence of pulmonary hypertension.
Population
10 mice undergoing experimental acute myocardial infarction involving the left ventricular free wall
Design
Preclinical
Follow-up
1 week
Authors
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RV dysfunction may follow LV MI without afterload change; hypothesis-generating in mice and leaves open human relevance.
Effect estimate: 33% decline
p-value: p=0.021
In a mouse model, acute myocardial infarction involving the left ventricle induces significant acute right ventricular systolic dysfunction independent of changes in right ventricular afterload.
Toldo et al. (2011) studied Acute Myocardial Infarction (n=20). Experimental acute myocardial infarction (left coronary artery ligation) vs. Sham surgery was evaluated on Right ventricular fractional area change (RVFAC) (33% decline, p=0.021). Experimental acute myocardial infarction involving the left ventricle induced a significant 33% decline in right ventricular fractional area change in the absence of pulmonary hypertension.
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