Key result
Reducing left ventricular volume to zero in isolated rabbit hearts caused a 5.7% decrease in right ventricular developed pressure (P<0.001), with further decreases upon coronary ligation and free wall cutting.
Why the study?
Do alterations in left ventricular volume and free wall function affect right ventricular developed pressure in isolated rabbit hearts?
Population
Isolated, flow-perfused, paced rabbit hearts beating isovolumically (N=10)
Comparison
Reducing left ventricular volume to zero… vs Baseline optimal LV volume and intact LV free wall
Design
Preclinical
Authors
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Rabbit heart data should not alter clinical RV management; leaves open translation of ventricular interdependence to humans.
Do alterations in left ventricular volume and free wall function affect right ventricular developed pressure in isolated rabbit hearts?
p-value: p=<0.001
Alterations in left ventricular free wall function and volume directly affect right ventricular developed pressure through the myocardium, likely via septal bulging.
Santamore et al. (1976) studied Right ventricular function (n=10). Reducing LV volume, coronary ligation, and cutting LV free wall vs. Baseline optimal LV volume was evaluated on Right ventricular developed pressure (RVDP) (p=<0.001). Reducing left ventricular volume to zero in isolated rabbit hearts caused a 5.7% decrease in right ventricular developed pressure (P<0.001), with further decreases upon coronary ligation and free wall cutting.
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