Increasing left ventricular volume from zero to two-thirds of peak volume increased right ventricular diastolic pressure by 1.7 mmHg (P<0.001) in isolated rabbit hearts.
Does varying the volume of one ventricle alter the diastolic and developed pressure-volume relationships of the other ventricle in isolated rabbit hearts?
This preclinical study demonstrates direct ventricular interdependence, showing that the diastolic and developed pressure-volume relationships of either ventricle are acutely altered by changes in the volume of the opposite ventricle.
Mean Difference: 1.7
p-value: p=<0.001
The myocardial interaction between the ventricles was studied using isolated, flow-perfused, paced rabbit hearts beating isovolumically. In general, increasing left ventricular (LV) volume increased right ventricular (RV) diastolic and developed pressures. In particular, with a peak RV volume (RVV), increasing LV volume (LVV) from zero to two-thirds of its peak volume increase RV diastolic pressure by 1.7 mmHg (N=10, P less than 0.001) and RV developed pressure by 1.5 mmHg (N=10,P less than 0.001). For the LV, small RVV caused LV diastolic and developed pressure to increase, while large RVV increased LV diastolic pressure but decreased LV developed pressure. With a LVV held at two-third of peak volume, increasing RVV from zero to its peak volume caused LV diastolic pressure to increase by 2.5 mmHg (N=10,P less than 0.001) and LV developed pressure to decrease by 2.0 mmHg (N=10, P less than 0.001). The position of the interventricular septum correlated with LV diastolic pressure and RV diastolic and developed pressure changes (P less than 0.01). The results demonstrate that the diastolic and developed pressure-volume relationships of either ventricle can be acutely altered by varying the volume of the other ventricle.
Santamore et al. (1976) studied this question. Increasing left ventricular volume vs. Zero left ventricular volume was evaluated on Right ventricular diastolic pressure (MD 1.7, p=<0.001). Increasing left ventricular volume from zero to two-thirds of peak volume increased right ventricular diastolic pressure by 1.7 mmHg (P<0.001) in isolated rabbit hearts.