Key result
Increasing right ventricular end-diastolic pressure from 10 to 15 mmHg with a closed pericardium resulted in approximately 1:1 coupling of the ventricles.
Why the study?
What are the independent contributions of the pericardium and septum to direct ventricular interaction?
Population
Intact animal right-heart bypass model
Comparison
Independent variation of left ventricular venous… vs Different levels of RVEDP and pericardium closed…
Design
Preclinical
Authors
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Pericardial constraint likely mediates ventricular coupling at high right ventricular pressures; extends mechanistic insights from animal models but leaves human applicability open.
What are the independent contributions of the pericardium and septum to direct ventricular interaction?
Direct ventricular interaction substantially affects LVEDP-volume relations, with the pericardium mediating coupling at high RVEDP and the septum contributing significantly even when the pericardium is open.
Baker et al. (1998) studied Direct ventricular interaction. Variation of right ventricular end-diastolic pressure and pericardium state was evaluated on RV-to-LV pressure gain (DeltaLVEDP/DeltaRVEDP). Increasing right ventricular end-diastolic pressure from 10 to 15 mmHg with a closed pericardium resulted in approximately 1:1 coupling of the ventricles.
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