Key result
Combined peritoneal dialysis and hemodialysis reduced the incidence of left ventricular hypertrophy from 76.4% to 61.8% compared to peritoneal dialysis alone (p=0.013).
Why the study?
Combined peritoneal dialysis and hemodialysis (PHD) is used for PD patients who experience technique failure, but cardiac structural and functional changes before and after PHD required investigation.
Does combined peritoneal dialysis and hemodialysis reduce left ventricular hypertrophy in patients with peritoneal dialysis technique failure?
Observational (n=58)
No
Does combined peritoneal dialysis and hemodialysis reduce left ventricular hypertrophy in patients with peritoneal dialysis technique failure?
Switching from peritoneal dialysis alone to combined peritoneal and hemodialysis significantly reduces left ventricular hypertrophy and left ventricular mass index in patients with peritoneal dialysis technique failure.
May support combined PD+HD in technique failure to limit LVH; hypothesis-generating and requires RCTs before practice change.
Background/Aims. Combined peritoneal dialysis and hemodialysis (PHD) are used in treating PD patients who underwent technique failure. This study aimed to research the cardiac structural and functional change in patients before and after PHD. Methods. This retrospective study enrolled 58 patients at The Second Affiliated Hospital of Soochow University who switched from PD to PHD. Clinical data and echocardiographic examination results were collected. Data from the two groups with a normal distribution were compared with the paired t‐test. A pvalue <0.05 (two‐tailed) was considered statistically significant. Results. A total of 58 subjects were enrolled, including 46 males and 12 females, with a median age of 50.2 ± 11.1 (47–68) years. The mean duration of peritoneal dialysis was 67.2 ± 33.6 months. Before and after PHD, the ultrafiltration volume (p = 0.021) and hemoglobin (p = 0.001) were increased, while SBP (p = 0.002), DBP (p = 0.002), phosphorus (p < 0.001), and ESA dosage (p < 0.001) were decreased. Before and after combined dialysis (PHD), the incidence of LVH was 76.4% and 61.8%, respectively (p = 0.013), and LVMI decreased from 173.8 ± 86.2 g/m2 to 160.6 ± 78.5 g/m2 (p < 0.001). Conclusion. Compared with PD alone, the combination of PD and HD resulted in regression of LVH and reduced LVMI.
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Gao et al. (2022) conducted an observational in Peritoneal dialysis technique failure (n=58). Combined peritoneal dialysis and hemodialysis (PHD) vs. Peritoneal dialysis (PD) alone (baseline) was evaluated on Incidence of left ventricular hypertrophy (LVH) (p=0.013). Combined peritoneal dialysis and hemodialysis reduced the incidence of left ventricular hypertrophy from 76.4% to 61.8% compared to peritoneal dialysis alone (p=0.013).
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