Key result
In rats, eucapnic hypoxia caused a greater elevation in systolic blood pressure and greater bradycardia compared with hypocapnic hypoxia.
Population
Sprague-Dawley (SD) and Wistar Kyoto (WKY) rats
Comparison
Repetitive 30-s cycles of eucapnic hypoxia… vs Repetitive 30-s cycles of hypocapnic hypoxia
Design
Preclinical
Authors
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Eucapnic hypoxia may augment sympathetic pressor responses versus hypocapnic hypoxia in rats; hypothesis-generating and leaves open human translation.
In a rat model, eucapnic hypoxia is a more potent stimulus for acute blood pressure elevation and bradycardia than hypocapnic hypoxia, mediated by increased sympathetic tone.
Bao et al. (1997) studied this question. Episodic eucapnic hypoxia vs. Episodic hypocapnic hypoxia was evaluated on Acute blood pressure elevation and bradycardia. In rats, eucapnic hypoxia caused a greater elevation in systolic blood pressure and greater bradycardia compared with hypocapnic hypoxia.
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