Key result
Type 2 diabetes is linked to a blunted heart rate-strain relationship during dobutamine stress.
Why the study?
Does dobutamine stress strain rate imaging detect impaired inotropic response in patients with type 2 diabetes mellitus without coronary artery disease compared to controls?
Population
n=40 (24 patients with type 2 diabetes mellitus and 16 controls), both free of coronary artery disease.
Comparison
Dobutamine stress with Doppler echocardiography… vs 16 control subjects free of coronary artery…
Design
Case-control
Authors
Loading...
Supports detection of subclinical contractile impairment in T2DM; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=40)
Does dobutamine stress strain rate imaging detect impaired inotropic response in patients with type 2 diabetes mellitus without coronary artery disease compared to controls?
Absolute Event Rate: -0.08% vs -0.14%
p-value: p=< .01
Strain rate imaging during dobutamine stress reveals impaired myocardial contractile reserve in patients with uncomplicated type 2 diabetes mellitus.
Galderisi et al. (2007) conducted an observational in Type 2 diabetes mellitus (n=40). Type 2 diabetes mellitus vs. Controls without diabetes was evaluated on Slope of the overall relation between heart rate and strain during dobutamine stress (p=< .01). Type 2 diabetes was associated with a blunted slope of the relation between heart rate and regional strain during dobutamine stress compared to controls (b = -0.08 vs -0.14, P < 0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: