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September 10, 2026Journal of Intensive Care Medicine

Infections in ECMO: A Comprehensive Review of the Epidemiology, Diagnosis, Management and Prevention

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Authors

EOErika R. OʼNeilJMJoseph E MarcusASAditya Shah

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Overview

Clinical review details the burden and risks of infections during extracorporeal membrane oxygenation, highlighting the need for refined diagnostic criteria and standardized multicenter research.

Key Points

  • To summarize the epidemiology, pathophysiology, diagnosis, prevention, and clinical management of infectious adverse events in patients receiving extracorporeal membrane oxygenation (ECMO).
  • Conducted a comprehensive literature review assessing infectious complications in adult and pediatric populations undergoing extracorporeal life support.
  • Evaluated diagnostic standards, therapeutic antimicrobials, and infection-control strategies across clinical ECMO management protocols.
  • Infections acquired while on extracorporeal support are frequent adverse events that significantly prolong hospital stays and increase healthcare resource consumption.
  • Infectious complications during ECMO correlate with higher overall patient mortality compared to uninfected courses.
  • Substantial heterogeneity in current definitions and surveillance highlights an urgent need for standardized multicenter data collection and rigorous prospective studies.

Cite This Study

OʼNeil et al. (2026) studied this question.

synapsesocial.com/papers/6aa27aca58559d80afc738cbhttps://doi.org/10.1177/08850666261487150
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