Key result
Reduced LVEF in septic cardiomyopathy shows no significant association with 28-day mortality.
Why the study?
The value of pulse index continuous cardiac output (PICCO) monitoring in assessing the relationship between cardiac function, haemodynamic evolution, and prognosis in patients with septic cardiomyopathy required investigation.
Does Pulse Index Continuous Cardiac Output (PICCO) monitoring identify differences in haemodynamic evolution and short-term mortality between septic cardiomyopathy patients with reduced (LVEF < 50%) versus normal (LVEF ≥ 50%) cardiac function?
Cohort (n=60)
Does Pulse Index Continuous Cardiac Output (PICCO) monitoring identify differences in haemodynamic evolution and short-term mortality between septic cardiomyopathy patients with reduced (LVEF < 50%) versus normal (LVEF ≥ 50%) cardiac function?
PICCO monitoring characterizes severe cardiac depression and a critical 24-hour haemodynamic decompensation window in septic cardiomyopathy patients with reduced LVEF, offering quantifiable targets for individualized critical care management.
Answers are grounded in this paper and cite their sources.
May identify high-risk septic cardiomyopathy for closer monitoring; leaves open whether PICCO-guided interventions improve outcomes.
Objective This study aimed to investigate the value of pulse index continuous cardiac output (PICCO) monitoring in assessing the relationship between cardiac function, haemodynamic evolution and prognosis in patients with septic cardiomyopathy (SCM). Methods Sixty patients with SCM were categorised into normal (left ventricular ejection fraction [LVEF] ≥ 50%, n = 21) and reduced (LVEF < 50%, n = 39) cardiac function groups. Haemodynamic parameters (cardiac index [CI], global end-diastolic volume index [GEDVI], systemic vascular resistance index [SVRI], extravascular lung water index and pulmonary vascular permeability index) were dynamically monitored via PICCO at 0, 6, 12, 24, 48 and 72 h. The 21-day mortality was recorded. Results The reduced group was significantly older (62.4 ± 11.9 vs 36.4 ± 8.7 years, P < .001) with higher Acute Physiology and Chronic Health Evaluation II scores ( P = .028) than the normal group. Their CI remained significantly lower than that of the normal group at all time points, reaching a nadir at 24 h (2.46 ± 0.62 vs 3.65 ± 1.03 L/min·m 2 , P < .001). Unlike the normal group, the reduced group showed a significant GEDVI rebound at 24 h ( P ≤ .05). No significant difference in SVRI was found between groups ( P > .05). The 28-day cumulative mortality was 38.5% in the reduced group versus 19.0% in the normal group ( P = .211). Conclusion Pulse index continuous cardiac output monitoring effectively identifies haemodynamic differences across SCM cardiac functions. Patients with reduced LVEF exhibit severe cardiac depression and a 24-h decompensation window. Although mortality differences were not statistically significant in this cohort, PICCO provides vital quantifiable targets for individualised management.
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Yuan et al. (2026) conducted a cohort in Septic cardiomyopathy (SCM) (n=60). Reduced cardiac function (LVEF < 50%) monitored via Pulse Index Continuous Cardiac Output (PICCO) vs. Normal cardiac function (LVEF ≥ 50%) monitored via PICCO was evaluated on 28-day cumulative mortality (p=0.211). Reduced LVEF in septic cardiomyopathy had lower 24-h cardiac index and non-higher 28-day mortality on PICCO.
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