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September 10, 2026Journal of the American Academy of Orthopaedic Surgeons

Contemporary Update on Fracture-Related Infection: A Multidisciplinary Approach to Evaluation, Prevention, and Treatment

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Authors

TMTimothy P. MurphyEWErin L. WeberEREvan D. Robinson

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Overview

Clinical review demonstrates standardized diagnostic and therapeutic strategies for fracture-related infection, highlighting multidisciplinary approaches to promote healing.

Key Points

  • To review current literature on consensus definitions, diagnostic workups, preventive strategies, and multidisciplinary treatment principles for fracture-related infections.
  • Synthesized contemporary literature evaluating the clinical, laboratory, and radiographic criteria for diagnosing fracture-related infection.
  • Examined multidisciplinary management protocols focused on infection eradication, microbial suppression, and mechanical fracture consolidation.
  • Consensus diagnostic criteria effectively standardize case definitions by combining clinical signs, serum and local biomarkers, and imaging findings.
  • Optimal patient outcomes require coordinated multidisciplinary protocols that balance surgical debridement and targeted antimicrobial therapy with rigid skeletal stabilization to achieve bone union.

Cite This Study

Murphy et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b8858559d80afc74be2https://doi.org/10.5435/jaaos-d-25-01632
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fracture-related infections of the lower extremity – Analysis of costs and their drivers2024 · 9 citations
  2. 2Effect of Preoperative Antibiotic Therapy on Operative Culture Yield for Diagnosis of Native Joint Septic Arthritis2024 · 6 citations
  3. 3A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds2015 · 369 citations
  4. 4The influence of duration of infection on outcome of debridement and implant retention in fracture-related infection2021 · 92 citations
  5. 5No Consensus on the Consensus: Failure to Adopt Fracture-Related Infection Definition at the Orthopedic Trauma Association Annual Meetings2025 · 1 citations