Key result
In patients with systolic heart failure, higher body mass index was inversely correlated with NT-proBNP levels (P=0.001), though heart rate variability indices did not differ between BMI groups.
Why the study?
Does body mass index affect heart rate variability and inflammatory parameters in patients with symptomatic systolic heart failure?
Cross-Sectional (n=55)
Does body mass index affect heart rate variability and inflammatory parameters in patients with symptomatic systolic heart failure?
p-value: p=0.001
In patients with systolic heart failure, higher BMI is associated with lower NT-proBNP levels, but not with differences in heart rate variability.
Calls for BMI-adjusted NT-proBNP interpretation in systolic HF; hypothesis-generating for autonomic and inflammatory effects.
BACKGROUND: To investigate the effect of body mass index (BMI) on heart rate variability (HRV) and inflammatory parameters in patients with heart failure. METHODS: We analyzed 55 consecutive patients (mean age, 63.5 +/- 12.8 years; male/female, 39/16) with symptomatic left ventricular systolic (ejection fraction <45%) heart failure. The participants were classified into three categories according to BMI: lean (BMI < 25 kg/m2), overweight (BMI = 25-29.9 kg/m2) and obese (BMI >or= 30 kg/m2). The cause of heart failure was mainly ischemic heart disease (75%) with mean ejection fraction 30 +/- 7%. Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and C-reactive protein levels were measured, and time-domain HRV indices were determined on Holter electrocardiogram. The relationship between HRV indices and laboratory, inflammatory and echocardiographic parameters was investigated with correlation analysis. RESULTS: Age, sex, clinical characteristics (hypertension, diabetes mellitus, dyslipidemia, family history, smoking) were similar between groups. BMI was inversely correlated with NT-pro BNP levels (P = 0.001). HRV indices did not differ between groups. Correlation analysis demonstrated the relationship between HRV indices and fasting blood glucose (SDNN, SDANN, SDNNI, root mean square successive differences, VTI), C-reactive protein (SDANN, SDNNI, VTI), pulmonary artery pressure (SDNN, SDANN, VTI) levels. CONCLUSION: In systolic heart failure patients a higher BMI is associated with decreased NT-proBNP levels. Although HRV indices were not different between groups, inflammatory parameters, fasting blood glucose and pulmonary artery pressure were correlated with them.
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Taçoy et al. (2010) conducted a cross-sectional in Symptomatic left ventricular systolic heart failure (n=55). Body mass index (BMI) vs. Lean (BMI < 25 kg/m2) vs overweight (BMI = 25-29.9 kg/m2) vs obese (BMI ≥ 30 kg/m2) was evaluated on Heart rate variability (HRV) indices and inflammatory parameters (NT-proBNP, C-reactive protein) (p=0.001). In patients with systolic heart failure, higher body mass index was inversely correlated with NT-proBNP levels (P=0.001), though heart rate variability indices did not differ between BMI groups.
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