Key result
Novel RSII mapping reveals higher stiffness in AAA walls with localized low-stiffness in dilated regions.
Why the study?
To determine potential clinical and CT imaging predictors for abdominal aortic aneurysm rupture by comparing patients with large unruptured versus ruptured aneurysms.
Do specific CT imaging characteristics and biomechanical indices predict abdominal aortic aneurysm rupture?
Observational (n=20)
Yes
Do specific CT imaging characteristics and biomechanical indices predict abdominal aortic aneurysm rupture?
CT imaging characteristics, such as the ratio of iliac arteries and infrarenal neck to maximum aneurysm diameter, along with biomechanical indices like the Relative Structural Integrity Index, may help predict the risk of rupture in abdominal aortic aneurysms.
May inform AAA biomechanical assessment; hypothesis-generating pending prospective validation.
BACKGROUND: The aim of this study is to determine potential clinical and computed tomography (CT) imaging predictors for abdominal aortic aneurysm (AAA) rupture based on a comparative analysis of patients presenting with large (>6.5 cm diameter) unruptured AAA (uAAA) and patients presenting with ruptured AAA (rAAA) respectively.METHODS: Consecutive patients presenting with large unruptured or rAAA and having undergone a contrast-enhanced CT at admission between January 2005 and June 2019 were included. Patients’ demographics and CT-imaging characteristics were collected from the institutional electronic medical records. Both patient groups were compared using Fisher’s Exact Test for categorical variables and the Mann-Whitney U Test for continuous variables.RESULTS: We included 101 patients, of which 57 patients presenting with a rAAA and 44 patients with a large, uAAA. Patients in the large, uAAA group were younger, mean age of 76 years vs. 83 years (P<0.001), had less coronary artery disease (47.6% vs. 72.5%; P=0.026) and had a lower left common iliac artery to maximum aneurysm diameter ratio (0.15 vs. 0.18; P=0.034), a lower sum of right + left common iliac artery to maximum aneurysm diameter ratio (0.31 vs. 0.39; P=0.028) and a lower infrarenal neck to maximum aneurysm diameter ratio (0.29 vs. 0.35; P=0.039).CONCLUSIONS: Patients with large, uAAA’s were younger with less coronary artery disease and presented with lower ratio of right + left common iliac artery to maximum aneurysm diameter as well as a lower ratio of infrarenal neck to maximum aneurysm diameter on CT-imaging compared to patients with rAAA.
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Hoste et al. (2025) conducted an observational in Abdominal aortic aneurysm (n=20). Relative Structural Integrity Index (RSII) assessment via 4D-CTA vs. Healthy aortic walls (within-patient comparison) was evaluated on Relative Structural Integrity Index (RSII) values and distribution. The novel Relative Structural Integrity Index (RSII) demonstrated consistent values across 20 patients, revealing that AAA walls exhibited higher stiffness than healthy aortic walls, with localized low-stiffness zones predominantly found in the most dilated regions.
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