Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2015Journal of HepatologyOpen Access

NAFLD: A multisystem disease

View Full Paper
Ask AI
Bookmark
Share

Authors

CBChristopher D. ByrneGTGiovanni Targher

Discussion

Loading...

Member takes

Overview

Narrative review demonstrates increased risks of cardiovascular, metabolic, and renal diseases in non-alcoholic fatty liver disease, highlighting systemic complications beyond liver-specific...

Key Points

  • To synthesize clinical evidence establishing non-alcoholic fatty liver disease (NAFLD) as a multisystem disease and evaluate its links to extra-hepatic chronic conditions.
  • Conducted a narrative review searching PubMed (1990–2014) using keywords combining non-alcoholic fatty liver disease with diabetes, cardiovascular disease, cardiovascular mortality, or chronic kidney disease.
  • Excluded non-English language publications and therapeutic trial evaluations.
  • Identified that NAFLD substantially elevates the risk for multiple extra-hepatic chronic diseases, specifically type 2 diabetes mellitus, cardiovascular and cardiac diseases, and chronic kidney disease.
  • Observed that while hepatic pathology promotes cirrhosis, liver failure, and hepatocellular carcinoma, cardiovascular disease accounts for the majority of deaths in NAFLD patients.

Cite This Study

Byrne et al. (2015) studied this question.

synapsesocial.com/papers/6aa28b71d081bdd435a72e39https://doi.org/10.1016/j.jhep.2014.12.012
View Full Paper
Ask AI
Bookmark
Share