Left Ventricular Remodeling and Improvement in Diastolic Function After Balloon Aortic Valvuloplasty for Congenital Aortic Stenosis
Key result
Balloon aortic valvuloplasty for congenital aortic stenosis significantly improved diastolic function, reducing E/E' from 14.2 to 10.8 (P<0.001).
Why the study?
Does balloon aortic valvuloplasty improve diastolic function and left ventricular remodeling in patients with congenital aortic stenosis?
Population
25 consecutive patients with congenital aortic stenosis, median age 11.5 years (range 3.2-40.1).
Design
Cohort
Follow-up
median 11 months
Authors
Discussion
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Member takes
Implication
Supports short-term diastolic benefit of BAV in congenital AS; extends echo observations but leaves open randomized confirmation.
Study Design
Type
Cohort (n=25)
Structured PICO
Does balloon aortic valvuloplasty improve diastolic function and left ventricular remodeling in patients with congenital aortic stenosis?
P
Population
25 consecutive patients (median age 11.5 years) undergoing balloon aortic valvuloplasty for congenital aortic stenosis, followed for a median of 11 months.
E
Exposure
Balloon aortic valvuloplasty (BAVP)
O
Outcome
Changes in echocardiographic and catheterization measures of left ventricular remodeling and diastolic function (including E/E', LV mass, and LV volume)surrogate
Main Result
Absolute Event Rate: 10.8% vs 14.2%
p-value: p=<0.001
Balloon aortic valvuloplasty in congenital aortic stenosis leads to favorable left ventricular remodeling and improved diastolic function.
Cite This Study
Friedman et al. (2012) conducted a cohort in Congenital aortic stenosis (n=25). Balloon aortic valvuloplasty vs. Pre-BAVP baseline was evaluated on Early diastolic mitral inflow velocity/tissue Doppler early diastolic velocity (E/E') (p=<0.001). Balloon aortic valvuloplasty for congenital aortic stenosis significantly improved diastolic function, reducing E/E' from 14.2 to 10.8 (P<0.001).