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The human Cdc42Hs protein is homologous to but contains a thirteen residue insertion with respect to the ras subfamily of GTP-binding proteins. The possible role of this region of structure has been investigated by model building. These studies suggest that this region could act as a conformational switch - in the ·on" conformation, it both covers the nucleotide binding site and forms an extension to the likely effector binding site; in the "off' conformation it is no longer able to bind effector.
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Sutcliffe et al. (1994) studied this question.
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